منابع مشابه
Viral quasispecies evolution.
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant spectra or mutant clouds termed viral quasispecies. Here we review the origin of the quasispecies concept and some biological implications of quasispecies dynamics. Two main aspects are addressed: (i) mutant clouds as reservoirs of phenotypic variants for virus adaptability and (ii) the internal inter...
متن کاملMemory in viral quasispecies.
Biological adaptive systems share some common features: variation among their constituent elements and continuity of core information. Some of them, such as the immune system, are endowed with memory of past events. In this study we provide direct evidence that evolving viral quasispecies possess a molecular memory in the form of minority components that populate their mutant spectra. The exper...
متن کاملCharacteristic time in quasispecies evolution.
The time a phenotype takes to achieve a stationary state from an initial condition depends on multiple factors. In particular, it is a function of both its fitness and its mutation rate. We evaluate the average time, referred to as the characteristic time, T(c), that the system takes to reach a final steady state of simple models of populations formed by self-replicative sequences. The dependen...
متن کاملHepatitis C Virus: Viral Quasispecies and Genotypes
Hepatitis C virus (HCV) mainly replicates in the cytoplasm, where it easily establishes persistent infection, resulting in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Due to its high rate of mutation, HCV forms viral quasispecies, categorized based on the highly variable regions in the envelope protein and nonstructural 5A protein. HCV possesses seven major genotypes, amon...
متن کاملReconstructing viral quasispecies from NGS amplicon reads
This paper addresses the problem of reconstructing viral quasispecies from next-generation sequencing reads obtained from amplicons (i.e., reads generated from predefined amplified overlapping regions). We compare the parsimonious and likelihood models for this problem and propose several novel assembling algorithms. The proposed methods have been validated on simulated error-free HCV and real ...
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ژورنال
عنوان ژورنال: Microbiology and Molecular Biology Reviews
سال: 2012
ISSN: 1092-2172,1098-5557
DOI: 10.1128/mmbr.05023-11